中文名称: | Iniparib | ||||
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英文名称: | Iniparib | ||||
别名: | 3-硝基-4-碘苯甲酰胺 4-Iodo-3-nitrobenzamide | ||||
CAS No: | 160003-66-7 | 分子式: | C7H5In2O3 | 分子量: | 292.03 |
CAS No: | 160003-66-7 | ||||
分子式: | C7H5In2O3 | ||||
分子量: | 292.03 |
包装规格:
10mg 50mg 100mg 200mg 500mg 1g 5g in glass bottle
溶解性:
溶于DMSO(100 mg/mL 超声)
产品描述:
一种不可逆的 PARP1 抑制剂,可用于三阴性乳腺癌的研究。
Iniparib, also known as SAR-240550; NSC-746045; BSI-201; IND-71677; NIBA; INO-2BA, is a small-molecule prodrug inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1) with potential chemosensitizing, radiosensitizing and antineoplastic activities. In vivo, PARP-1 inhibitor BSI-201 is converted to the active drug, which selectively binds to PARP-1 and inhibits PARP-1- mediated DNA repair. Consequently, this agent may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapy and radiation therapy. In addition, PARP-1 inhibitor BSI-201 may exhibit direct antineoplastic activity against cancers defective in DNA repair.
Iniparib, also known as SAR-240550; NSC-746045; BSI-201; IND-71677; NIBA; INO-2BA, is a small-molecule prodrug inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1) with potential chemosensitizing, radiosensitizing and antineoplastic activities. In vivo, PARP-1 inhibitor BSI-201 is converted to the active drug, which selectively binds to PARP-1 and inhibits PARP-1- mediated DNA repair. Consequently, this agent may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapy and radiation therapy. In addition, PARP-1 inhibitor BSI-201 may exhibit direct antineoplastic activity against cancers defective in DNA repair.
保存条件:
-20℃
UN码:
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参考文献 & 客户发表文献
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质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )