中文名称: | 奎诺二甲基丙烯酸酯 促销 | ||||
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英文名称: | (±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid | ||||
别名: | 奎诺二甲基丙烯酸酯 Trolox | ||||
CAS No: | 53188-07-1 | 分子式: | C14H18O4 | 分子量: | 250.29 |
CAS No: | 53188-07-1 | ||||
分子式: | C14H18O4 | ||||
分子量: | 250.29 | ||||
MDL: | MFCD00006846 | EINEC: | 258-422-8 | ||
EINEC: | 258-422-8 |
基本信息
产品编号: |
H70020 |
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产品名称: |
(±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid |
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CAS: |
53188-07-1 |
储存条件 |
粉末 |
2-8℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
两年 |
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分子量 |
250.29 |
-20℃ |
一个月 |
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化学名: |
3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid |
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Solubility (25°C): |
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体外:
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DMSO |
50mg/mL (199.76mM) |
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Ethanol |
50mg/mL (199.76mM) |
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Water |
Insoluble |
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体内(现配现用): |
1.请依序添加每种溶剂:10% DMSO→40% PEG300→5% Tween-80→45% saline Solubility: ≥ 2.08mg/mL (8.31mM); Clear solution |
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此⽅案可获得 ≥ 2.08mg/mL (8.31mM,饱和度未知) 的澄清溶液。 以 1mL ⼯作液为例,取 100μL 20.8mg/mL 的澄清 DMSO 储备液加到 400μL PEG300 中,混合均匀;向上述体系中加⼊ 50μL Tween-80,混合均匀;然后继续加⼊ 450μL ⽣理盐⽔定容⾄ 1mL。 |
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2.请依序添加每种溶剂:10% DMSO→90% (20% SBE-β-CD in saline) Solubility: ≥ 2.08mg/mL (8.31mM); Clear solution |
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此⽅案可获得 ≥ 2.08mg/mL (8.31mM,饱和度未知) 的澄清溶液。 以 1mL ⼯作液为例,取 100μL 20.8mg/mL 的澄清 DMSO 储备液加到 900μL 20% 的 SBE-β-CD ⽣理盐⽔⽔溶液中,混合均匀。 |
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3.请依序添加每种溶剂:10% DMSO→90% corn oil Solubility: ≥ 2.08mg/mL (8.31mM); Clear solution |
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此⽅案可获得 ≥ 2.08mg/mL (8.31mM,饱和度未知) 的澄清溶液,此⽅案不适⽤于实验周期在半个⽉以上的实验。 以 1mL ⼯作液为例,取 100μL 20.8mg/mL 的澄清 DMSO 储备液加到 900μL ⽟⽶油中,混合均匀。 |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
3.9954mL |
19.9768mL |
39.9537mL |
5mM |
0.7991mL |
3.9954mL |
7.9907mL |
10mM |
0.3995mL |
1.9977mL |
3.9954mL |
50mM |
0.0799mL |
0.3995mL |
0.7991mL |
生物活性
产品描述 |
一种来源于水溶性维生素e的抗氧化剂,具有自由基清除和抗氧化活性。 |
靶点 |
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体外研究 |
Trolox has shown to protect mammalian cells from oxidative damage. Trolox is effective in preventing myocyte necrosis in cell culture studies and in a canine model of two hours of left anterior descending coronary artery (LAD) occlusion followed by four hours of reperfusion. Trolox could prevent oxidative stress-induced apoptosis in thymocytes. Pre- or posttreatment of cells with Trolox reduced H 2O2-induced DNA fragmentation to control levels and below. Trolox is a hydrophilic analogue of alpha-tocopherol and reported to scavenge peroxyl radicals better than vitamin E in sodium dodecyl sulfate micelles and in liposomes. Trolox prolongs substantially the survival of human ventricular myocytes and hepatocyte against oxyradicals generated with xanthine oxidase plus hypoxanthine, and prevented lysis of red cells exposed to an azo-initiator |
推荐实验方法(仅供参考)
Cell Assay |
Thymocytes are treated with Trolox (10mM) before, during, or after 10 min exposure to 10μM H2O2. Trolox incubations that are conducted before or after H2O2 exposures are performed in TCM. Trolox treatments that are administered concurrently with H2O2 are performed in PBS with ferrous sulfate |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )