中文名称: | 硫酸乙酰肝素 | ||||
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英文名称: | Heparan Sulfate | ||||
别名: | 硫酸乙酰肝素 | ||||
CAS No: | 9050-30-0 | 分子式: | C12H19NO20S3(MoNOMEr) | 分子量: | 593.47 (monomer) |
CAS No: | 9050-30-0 | ||||
分子式: | C12H19NO20S3(MoNOMEr) | ||||
分子量: | 593.47 (monomer) |
基本信息
产品编号:H10551 |
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产品名称:Heparan Sulfate |
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CAS: |
9050-30-0 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
六个月 |
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分子量 |
593.47 |
-20℃ |
一个月 |
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化学名: |
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Solubility (25°C) |
体外 |
DMSO |
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Ethanol |
Insoluble |
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Water |
Insoluble |
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体内(现配现用) |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
生物活性
产品描述 |
一种复杂的线性多糖。它作为硫酸乙酰肝素蛋白聚糖的一部分出现,在细胞表面和细胞外基质中表达丰富。 |
靶点/IC50 |
Human Endogenous Metabolite |
体外研究 |
Heparan sulfate is a linear polysaccharide and belongs to the family of glycosaminoglycans. Heparan sulfate is composed of glucuronic acid (GlcA) and iduronic acid (IdoA) residues as well as N-acetyl glucosamines (GlcNAc) with various sulfation modifications, and is typically 50-200 disaccharides in length. Heparan sulfate interacts with numerous proteins, including growth factors, morphogens, and adhesion molecules, and thereby regulates important developmental processes in invertebrates and vertebrates. Heparan sulfate chains regulate developmental signaling by acting as co-factors through a variety of mechanisms that include but are not limited to maintenance of morphogen gradients and co-receptor functions. Heparan sulfate proteoglycans can act as receptors for proteases and protease inhibitors regulating their spatial distribution and activity. Membrane Heparan sulfate proteoglycans act as coreceptors for various tyrosine kinase-type growth factor receptors, lowering their activation threshold or changing the duration of signaling reactions. Heparan sulfate influences the binding affinity of intestinal epithelium cells to Wnt, thereby promoting activation of canonical Wnt signaling and facilitating regeneration of small intestinal crypts after epithelial injury. |
体内研究 |
Digestion of heparan sulfate impairs context discrimination in a fear conditioning paradigm and oscillatory network activity in the low theta band after fear conditioning. Thus, heparan sulfate maintains neuronal excitability and, as a consequence,support synaptic plasticity and learning.FGF-2/FGFR system is involved in the regulation of astrocytic reactivity and/or proliferation in the brain and its action is potentiated by heparan sulfate. |
推荐实验方法(仅供参考)
动物实验: |
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Rats: Sprague-Dawley male rats 3-4 months old receive aspiration of a small segment of the motor-sensory cortex in both hemispheres. Groups of rats (n=5) receive a piece of Gelfoam embedded with human recombinant FGF-2, heparan sulfate (10kg/mL; sodium salt, bovine kidney) dissolved in PBS, or both, in the right hemisphere. The wound cavity of the left hemisphere receives a piece of Gelfoam embedded with saline. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )