基本信息
产品编号: |
H10332 |
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产品名称: |
Hematein |
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CAS: |
475-25-2 |
储存条件 |
粉末 |
室温 |
四年 |
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分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量 |
300.26 |
-20℃ |
1个月 |
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化学名: |
3,4,6a,10-tetrahydroxy-6,7-dihydroindeno[2,1-c]chromen-9-one |
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Solubility (25°C): |
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体外:
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DMSO |
100 mg/mL (333.04mM; Need ultrasonic) |
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Water |
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Ethanol |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
3.3304mL |
16.6522mL |
33.3045mL |
5mM |
0.6661mL |
3.3304mL |
6.6609mL |
10mM |
0.3330mL |
1.6652mL |
3.3304mL |
生物活性
产品描述 |
一种变构酪蛋白激酶 II 抑制剂,IC50 为 0.74μM。 |
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靶点 |
CKII 0.74μM (IC50) |
Akt |
Wnt |
体外研究 |
Hematein (10-100μM; 14 days) inhibits cells growth in A427 lung cancer cells.
Cell Viability Assay |
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Cell Line: |
A427 (HTB-53) cell line |
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Concentration: |
10-100μM |
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Incubation Time: |
14 days |
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Result: |
Inhibited cells growth. |
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Apoptosis Analysis |
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Cell Line: |
A427 (HTB-53) cell line |
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Concentration: |
50 and 100μM |
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Incubation Time: |
48 hours |
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Result: |
Induced apoptosis in A427 lung cancer cells. |
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Western Blot Analysis |
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Cell Line: |
A427 (HTB-53) cell line |
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Concentration: |
50 and 100μM |
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Incubation Time: |
48 hours |
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Result: |
Inhibited CK2-specific Akt phosphorylation. |
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体内研究 |
Hematein (intraperitoneal injections; 50 mg/kg; twice a week for 6 weeks) inhibits tumor growth in A427 lung cancer cell xenografts. |
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Animal Model: |
Female athymic BALB/c nude mice (6-week-old) [1] |
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Dosage: |
50 mg/kg |
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Administration: |
Intraperitoneal injections; twice a week for 6 weeks |
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Result: |
Inhibited tumor growth in A427 lung cancer cell xenografts. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )