(R)-GNE-140 - CAS:2003234-63-5 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	(R)-GNE-140 促销
英文名称:	(R)-GNE-140
别名:	(R)-3-((2-氯苯基)硫基)-4-羟基-6-(4-吗啉苯基)-6-(噻吩-3-基)-5,6-二氢吡啶-2(1H)-酮 (R)-3-((2-Chlorophenyl)thio)-4-hydroxy-6-(4-morpholinophenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one
CAS No:	2003234-63-5	分子式:	C₂₅H₂₃ClN₂O₃S₂	分子量:	499.04
CAS No:	2003234-63-5
分子式:	C₂₅H₂₃ClN₂O₃S₂
分子量:	499.04

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G10600 (R)-GNE-140 ≥98% (psaitong)

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包装规格：

2mg 5mg 10mg 50mg 100mg in glass bottle

溶解性：

溶于DMSO(≥10mg/ml)

产品描述：

一种有效的LDHA抑制剂。
R-GNE-140 a novel potent lactate dehydrogenase (LDHA) inhibitor with IC50 3nM for LDHA and 5 nM for LDHB. In MIA PaCa-2 human pancreatic cells, LDHA inhibition rapidly affected global metabolism, although cell death only occurred after 2 d of continuous LDHA inhibition. Pancreatic cell lines that utilize oxidative phosphorylation (OXPHOS) rather than glycolysis were inherently resistant to GNE-140, but could be resensitized to GNE-140 with the OXPHOS inhibitor phenformin. Acquired resistance to GNE-140 was driven by activation of the AMPK-mTOR-S6K signaling pathway, which led to increased OXPHOS, and inhibitors targeting this pathway could prevent resistance.

保存条件：

-20℃

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