中文名称: | GTS-21 dihydrochloride | ||||
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英文名称: | GTS-21 dihydrochloride | ||||
别名: | (1:2),(3E)-3-[(2,4-二甲氧基苯基)亚甲基]-3,4,5,6-四氢-2,3-联吡啶盐酸盐;(3E)-3-[(2,4-二甲氧基苯基)亚甲基]-3,4,5,6-四氢-2,3'-联吡啶二盐酸盐 3-[(5E)-5-[(2,4-dimethoxyphenyl)methylidene]-3,4-dihydro-2H-pyridin-6-yl]pyridine;dihydrochloride | ||||
CAS No: | 156223-05-1 | 分子式: | C??H??Cl?N?O? | 分子量: | 381.3 |
CAS No: | 156223-05-1 | ||||
分子式: | C??H??Cl?N?O? | ||||
分子量: | 381.3 |
基本信息
产品编号: |
G10437 |
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产品名称: |
GTS-21 dihydrochloride |
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CAS: |
156223-05-1 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
381.30 |
-20℃ |
1个月 |
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化学名: |
2,3'-Bipyridine,3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-,hydrochloride (1:2),(3...;2,3'-Bipyridine,3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-,hydrochloride (1:2),(3E)- |
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Solubility (25°C): |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
2.6226mL |
13.1130mL |
26.2261mL |
5mM |
0.5245mL |
2.6226mL |
5.2452mL |
10mM |
0.2623mL |
1.3113mL |
2.6226mL |
生物活性
产品描述 |
一种选择性α7烟碱乙酰胆碱受体(α7-nAChR)激动剂。 |
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靶点 |
α7-nAChR |
human α4β2 20nM (Ki) |
5-HT3A Receptor 3.1μM (IC50) |
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体外研究 |
GTS-21 bound to human α4β2 nAChR (Ki=20nM) 100-fold more potently than to humanα7-nAChR,and is 18- and 2-fold less potent than (-)-nicotine at human α4β2 and a7 nAChR,respectively. |
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体内研究 |
GTS 21 (4mg/kg;i.p.;1,3,7,14 and 21 days) reduces radiation induced histological signs of pulmonary injury. |
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Animal Model: |
C57BL6 mice were irradiated with 12 Gy to induce a mouse model of Radiation induced lung injury (RILI) |
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Dosage: |
4mg/kg |
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Administration: |
I.p.;1,3,7,14 and 21 days |
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Result: |
Reduces lung inflammatory infiltrate and fibrosis in radiation treated mice. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )