| 中文名称: | FW1256 | ||||
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| 英文名称: | FW1256 | ||||
| 别名: | 1,3,2-Benzoxazaphosphole, 2,3-dihydro-2-phenyl-, 2-sulfide | ||||
| CAS No: | 117089-08-4 | 分子式: | C12H10NOPS | 分子量: | 247.25 |
| CAS No: | 117089-08-4 | ||||
| 分子式: | C12H10NOPS | ||||
| 分子量: | 247.25 | ||||
基本信息
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产品编号： |
F10287 |
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产品名称： |
FW1256 |
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CAS: |
117089-08-4 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
247.25 |
-20℃ |
1个月 |
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化学名： |
1,3,2-Benzoxazaphosphole,2,3-dihydro-2-phenyl-,2-sulfide |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
4.0445mL |
20.2224mL |
40.4449mL |
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5mM |
0.8089mL |
4.0445mL |
8.0890mL |
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10mM |
0.4044mL |
2.0222mL |
4.0445mL |
生物活性
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产品描述 |
一种苯基类似物，也是一种缓释硫化氢(H2S)供体。 |
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靶点 |
NF-κB;Apoptosis |
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体外研究 |
FW1256 (200µM;24.5 hours;AW264.7 cells) treatment significantly reduces IL-1β,COX-2 and iNOS mRNA and protein in LPSstimulated RAW264.7 macrophages.FW1256 (200µM;24.5 hours;AW264.7 cells) treatment significantly reduces IL-1β,COX-2 and iNOS PROTE and protein in LPSstimulated RAW264.7 macrophages.FW1256 concentration dependently decreases TNF-α(IC50 of 61.2µM),IL-6 (IC50 of 11.7µM),PGE2 (IC50 of 25.5µM) and NO (IC50 of 34.6µM) generation in LPS-stimulated RAW264.7 macrophages and bone marrow-derived macrophages (BMDMs) (IC50s of 414.9µM,300.2µM,4µM and 9.5µM for TNF-α,IL-6,PGE2 and NO,respectively).FW1256 decreases NF-κB activation as evidenced by reduced cytosolic phospho-IκBα levels and reduces nuclear p65 levels in LPS-stimulated RAW264.7 macrophages treated with FW1256. RT-PCR |
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Cell Line: |
RAW264.7 cells |
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Concentration: |
200µM |
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Incubation Time: |
24.5 hours |
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Result: |
Significantly reduced IL-1β,COX-2 and iNOS mRNA in LPS-stimulated RAW264.7 macrophages.. |
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Western Blot Analysis |
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Cell Line: |
RAW264.7 cells |
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Concentration: |
200µM |
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Incubation Time: |
24.5 hours |
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Result: |
Significantly reduced IL-1β,COX-2 and iNOS proteinin LPS-stimulated RAW264.7 macrophages.. |
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体内研究 |
FW1256 (100mg/kg;intraperitoneal injection;male C57BL/6 mice) treatment reduces IL-1β,TNFα,nitrate/nitrite and PGE2 levels in LPS-treated mice. |
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Animal Model: |
Male C57BL/6 mice (20-25g,6-10 weeks) injected with E.coli lipopolysaccharide (LPS) |
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Dosage: |
100mg/kg |
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Administration: |
Intraperitoneal injection |
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Result: |
Reduced IL-1β,TNFα,nitrate/nitrite and PGE2 levels in LPS-treated mice. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
