基本信息
产品编号: |
F10166 |
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产品名称: |
Fucoidan |
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CAS: |
9072-19-9 |
储存条件 |
粉末 |
室温 |
四年 |
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分子式: |
溶于液体 |
-80℃ |
两年 |
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分子量 |
242.25 |
-20℃ |
一个月 |
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化学名: |
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Solubility (25°C): |
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体外:
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DMSO |
Insoluble |
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Ethanol |
Insoluble |
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Water |
48mg/mL |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
生物活性
产品描述 |
一种富含岩藻糖的硫酸多糖,对褐藻糖胶的研究发现它具有广泛的生物活性,包括抗肿瘤和抗血管生成活性、免疫调节、抗炎、抗凝血、抗血栓形成和抗氧化活性。 褐藻糖胶诱导巨噬细胞活化,随后激活促分裂原活化蛋白激酶(MAPK),并导致自然杀伤细胞增殖。 褐藻糖胶作为非选择性选择素阻断剂起作用,已被证明可诱导细胞凋亡并抑制血管生成。 |
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靶点 |
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体外研究 |
Fucoidan is a biologically active polysaccharide found in great abundance in brown marine algae. Fucoidan extracted from A. nodosum is a more potent inhibitor of α-glucosidase, with an IC50 ranging from 0.013 to 0.047mg/mL, than the inhibition by Fucoidan extracted from F. vesiculosus (IC50=0.049mg/mL). Fucoidan extracted from F. vesiculosus does not inhibit α-amylase activity, while Fucoidan from A. nodosum decreases α-amylase activity by 7-100% at 5mg/mL depending upon the algae harvest period. Fucoidan from A. nodosum inhibits α-amylase with an IC50 of 0.12-4.64mg/mL. Fucoidan is a fucose-rich sulfated polysaccharide typically found in the cell wall of marine algae but also recently isolated from terrestrial sources. Fucoidan exhibits an attractive therapeutic potential against a wide array of metabolic diseases associated with oxidative stress |
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体内研究 |
Fucoidan (single injection of 25mg/kg/body) does not inhibit tumor cell proliferation, while three-time injections of 10mg/kg/body weight significantly reduces tumor growth and metastasis |
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Animal Model: |
Mice |
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Dosage: |
10-400mg/kg |
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Administration: |
Intraperitoneal injection; followed by total-body irradiation |
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Result: |
The mice injected with 100mg/kg showed the best survival rate at 30 days post-irradiation. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )