中文名称: | Etalocib | ||||
---|---|---|---|---|---|
英文名称: | Etalocib | ||||
别名: | LY293111; VML 295 | ||||
CAS No: | 161172-51-6 | 分子式: | C33H33FO6 | 分子量: | 544.61 |
CAS No: | 161172-51-6 | ||||
分子式: | C33H33FO6 | ||||
分子量: | 544.61 |
基本信息
产品编号: |
E10354 |
||||
产品名称: |
Etalocib |
||||
CAS: |
161172-51-6 |
储存条件 |
粉末 |
-20℃ |
四年 |
|
|
||||
分子式: |
溶于液体 |
-80℃ |
6个月 |
||
分子量: |
544.61 |
-20℃ |
1个月 |
||
化学名: |
2-[3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenoxy]benzoic acid |
||||
Solubility (25°C): |
|||||
体外:
|
DMSO |
|
|||
Ethanol |
'mg/mL |
||||
Water |
|
||||
体内(现配现用): |
|
||||
<1mg/ml表示微溶或不溶。 |
|||||
普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
|||||
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
1.8362mL |
9.1809mL |
18.3618mL |
5mM |
0.3672mL |
1.8362mL |
3.6724mL |
10mM |
0.1836mL |
0.9181mL |
1.8362mL |
生物活性
产品描述 |
是具有口服活性的白三烯 (LTB4) 受体的拮抗剂,抑制 [3H]LTB4 结合的Ki 值为 25nM.Etalocib (LY293111) 抑制LTB4 诱导的钙动员的 lC50 值为 20nM。 |
||
靶点 |
Leukotriene Receptor |
Apoptosis |
|
体外研究 |
Etalocib (LY293111) elicits a concentration-dependent inhibition of LTB4 induced CD11b up-regulation.Etalocib (LY293111) is an extremely potent and selective antagonist of human neutrophil function in vitro.Etalocib (LY293111, 250 and 500 nM, 24-72 h) induces apoptosis and inhibits proliferation in human pancreatic cancer cells. Cell Proliferation Assay |
||
Cell Line: |
MiaPaCa-2 and AsPC-1 human pancreatic cancer cells. |
||
Concentration: |
500nM. |
||
Incubation Time: |
24,48,and 72h. |
||
Result: |
Caused both a concentration-dependent and time-dependent inhibition of thymidine incorporation in both MiaPaCa-2 and AsPC-1 human pancreatic cancer cells. |
||
Apoptosis Analysis |
|||
Cell Line: |
MiaPaCa-2 and AsPC-1 human pancreatic cancer cells. |
||
Concentration: |
250 and 500nM. |
||
Incubation Time: |
24h. |
||
Result: |
Induced apoptosis in human pancreatic cancer cells. |
||
体内研究 |
Etalocib (LY293111) produces a dose-related inhibition of acute leukotriene B4-induced airway obstruction when administered i.v.(ED50=14µg/kg) or p.o. (ED50=0.4mg/kg).Etalocib (LY293111,10mg/kg) inhibits A23187-induced lung inflammatory changes at 1h.Etalocib (LY293111,250mg/kg/day,orally) inhibits growth of human pancreatic cancer xenografts in athymic mice. |
||
Animal Model: |
Guinea pigs. |
||
Dosage: |
1-10mg/kg. |
||
Administration: |
Orally once. |
||
Result: |
A single 1mg/kg oral dose inhibited excised lung gas volume increases by 76.7±7.1% (n=4,P<0.002) when given 8h prior to leukotriene B4 challenge,and 28.6±20.3% (n=4,NS) when given 24h before challenge.Had no effect (10mg/kg) on pulmonary gas trapping at 1h or 2h after A23187 challenge.However,at 4h,the pulmonary gas trapping response was significantly less than that of vehicle-treated controls and not different from sham values.The 10mg/kg dose inhibited A23187-induced lung inflammatory changes at 1h,but was without effect at 2h or 4h after challenge. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )