中文名称: | 依布硒 | ||||
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英文名称: | Ebselen | ||||
别名: | 依布硒 SPI1005;DR3305;PZ51;2-phenylbenzo[d][1,2]selenazol-3(2H)-one | ||||
CAS No: | 60940-34-3 | 分子式: | C13H9NOse | 分子量: | 274.18 |
CAS No: | 60940-34-3 | ||||
分子式: | C13H9NOse | ||||
分子量: | 274.18 |
基本信息
产品编号: |
E10264 |
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产品名称: |
Ebselen |
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CAS: |
60940-34-3 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
274.18 |
-20℃ |
1个月 |
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化学名: |
2-phenylbenzo[d][1,2]selenazol-3(2H)-one |
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Solubility (25°C): |
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体外:
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DMSO |
55mg/mL (200.59mM) |
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Ethanol |
Insoluble |
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Water |
Insoluble |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
3.6472mL |
18.2362mL |
36.4724mL |
5mM |
0.7294mL |
3.6472mL |
7.2945mL |
10mM |
0.3647mL |
1.8236mL |
3.6472mL |
生物活性
产品描述 |
一种谷胱甘肽过氧化物酶模拟物,是有效的电压依赖性钙通道(VDCC)阻断剂。 |
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靶点 |
IC50:0.67μM (Mpro) EC50:4.67μM (COVID-19 virus) |
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体外研究 |
Ebselen (SPI-1005;0.4-100μM;20-24 hours) shows strong antiviral effects at a concentration of 10μM treatment in COVID-19 virus infected Vero cells.Ebsele covalently binds to C145 of the catalytic dyad in COVID-19 virus Mpro.Ebselen inhibits early viral postentry events of the HIV-1 life cycle by impairing the incoming capsid uncoating process.Ebselen permeates the blood-brain barrier and inhibits endogenous inositol monophosphatase in mouse brain.Ebselen inhibits inositol monophosphatase (IMPase).Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic,renal cancer cell lines. RT-PCR |
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Cell Line: |
COVID-19 virus infected Vero cells |
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Concentration: |
0.4,1.2,3.7,11.1,33.3,100μM |
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Incubation Time: |
20-24 hours |
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Result: |
Showed strong antiviral effects at a concentration of 10μM treatment. |
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体内研究 |
Ebselen (5,10mg/kg;IP) decreases 5-HT2 agonist-induced head twitches in a dose-dependent manner. |
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Animal Model: |
20-25g 10-12 week old male C57Bl6 mice |
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Dosage: |
5,10mg/kg |
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Administration: |
IP |
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Result: |
Decreased 5-HT2 agonist-induced head twitches in a dose-dependent manner. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )