| 中文名称: | 右旋普拉克索 | ||||
|---|---|---|---|---|---|
| 英文名称: | Dexpramipexole | ||||
| 别名: | 右旋普拉克索 (R)-Pramipexole; R-(+)-Pramipexole; KNS-760704 | ||||
| CAS No: | 104632-28-2 | 分子式: | C10H17N3S | 分子量: | 211.33 |
| CAS No: | 104632-28-2 | ||||
| 分子式: | C10H17N3S | ||||
| 分子量: | 211.33 | ||||
神经保护剂，是弱的非麦角类多巴胺受体激动剂。
Dexpramipexole, also known as KNS-760704 and (R)-Pramipexole, is under development for the treatment of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease. The drug failed to show efficacy in terms of function or survival in a Phase III study of patients with ALS. Dexpramipexole is a low molecular weight, water-soluble, orally bioavailable, renally excreted compound with linear pharmacokinetics, and has been shown to be well tolerated in human subject testing. KNS-760704 is the enantiomer of pramipexole, and has been shown to improve mitochondrial function and to confer significant cellular protection in neurons under stress. A 2010 Phase II clinical trial involving 102 patients showed a slowing of ALS disease progression.[5] In January 2013, Biogen Idec announced that it was discontinuing its development of dexpramipexole in ALS due to lack of efficacy in a Phase III study.[1]
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
