中文名称: 盐酸决奈达隆
英文名称: Dronedarone Hydrochloride
CAS No: 141625-93-6
分子式: C31H44N2O5S.HCl
分子量: 593.22
D10795 盐酸决奈达隆 ≥98% (psaitong)
包装规格:
1g 5g in glass bottle
溶解性:
溶于DMSO(≥ 50 mg/mL)
产品描述:

基本信息

产品编号:

D10795

产品名称:

Dronedarone Hydrochloride

CAS:

141625-93-6

 

储存条件

粉末

2-8℃

四年

 

 

分子式:

C31H44N2O5S.HCl

溶于液体

-80℃

6个月

分子量:

593.22

-20℃

1个月

化学名: 

4-((4-fluoro-2-methyl-1h-indol-5-yl)oxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline maleate

Solubility (25°C):

 

体外:

 

DMSO

80mg/mL (134.85mM)

Ethanol

40mg/mL (67.42mM)

Water

Insoluble

体内(现配现用):

 

1mg/ml表示微溶或不溶。

普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。

 

制备储备液

 

浓度

 

溶液体积

质量

 

1mg

 

5mg

 

10mg

1mM

1.6857mL

8.4286mL

16.8572mL

5mM

0.3371mL

1.6857mL

3.3714mL

10mM

0.1686mL

0.8429mL

1.6857mL

 

生物活性

产品描述

一种非碘化胺碘酮衍生物,可抑制Na+,K+ and Ca2+的电流。

靶点

Potassium Channel

Autophagy

 

体外研究

Dronedarone (SR-33589) is a multichannel blocker for atrial fibrillation.It is a potent inhibitor of the acetylcholine-activated K+ current from atrial and sinoatrial nodal tissue,and inhibits the rapid delayed rectifier more potently than slow and inward rectifier K+ currents and inhibits L-type calcium current. Under whole-cell patch clamp,it blocks IKr (IC50=3μM) and ICa-L (IC50=0.18μM).The effects on ICa-L are use- and frequency-dependent.Dronedarone inhibits current carried by human ether-ago-go gene (HERG)-expressing oocytes (analagous to IKr) with an IC50 of 9μM.In guinea pig ventricular myocytes,dronedarone exhibits a state dependent inhibition of the fast Na+ channel current with an IC50 of 0.7±0.1μM,when the holding potential is −80 mV.

体内研究

Dronedarone (Hydrochloride) reduces significantly the incidence of ventricular fibrillation (VF) from 80 to 30% (p<0.05) at 3mg/kg i.v.and eliminated VF and mortality at 10mg/kg i.v..Dronedarone inhibited carotid artery thrombus formation in vivo.Thrombin- and collagen-induced platelet aggregation is impaired indronedarone-treated mice (P\0.05),and expression ofplasminogen activator inhibitor-1 (PAI1),an inhibitor of the fibrinolytic system,is reduced in the arterial wall.

 

推荐实验方法(仅供参考)

动物实验:

 

Rats:Rats are anesthetized,artificially ventilated,and the thorax opened by a left thoracotomy.Ischemia is induced by left coronary artery ligation,and reperfusion is achieved (after a 5-min period of ischemia) in a separate group of rats by removing the ligature.Agents are given intravenously 5 min before occlusion or orally 4h before study.

Mice:Twelve-week-old C57Bl/6 mice are divided into two groups:dronedarone (200mg/kg body weight with a once daily oral gavage for 14 days) or control (1.4% methylcellulose). Twenty-four hours after the last application,mice are anesthetized by intraperitoneal injection of 87mg/kg sodium pentobarbital.Rose bengal is diluted to 12mg/mL in phosphate-buffered saline and then injected into the tail vein at a concentration of 63mg/kg.

保存条件:
2-8℃
UN码:
HazardClass:
危害声明:
安全说明:
搜索质检报告(COA)
参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • =
    *
    *
    *选择对应的单位 *空出希望得到的变量,填写另外两个变量

用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )

  • * = *

连续稀释计算器方程

  • 连续稀释

  • 初始浓度:
  • 稀释倍数:
  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):