中文名称: | 盐酸决奈达隆 | ||||
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英文名称: | Dronedarone Hydrochloride | ||||
别名: | 盐酸决奈达隆 Dronedarone Hydrochloride | ||||
CAS No: | 141625-93-6 | 分子式: | C31H44N2O5S.HCl | 分子量: | 593.22 |
CAS No: | 141625-93-6 | ||||
分子式: | C31H44N2O5S.HCl | ||||
分子量: | 593.22 | ||||
MDL: | MFCD00914940 |
基本信息
产品编号: |
D10795 |
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产品名称: |
Dronedarone Hydrochloride |
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CAS: |
141625-93-6 |
储存条件 |
粉末 |
2-8℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
593.22 |
-20℃ |
1个月 |
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化学名: |
4-((4-fluoro-2-methyl-1h-indol-5-yl)oxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline maleate |
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Solubility (25°C): |
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体外:
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DMSO |
80mg/mL (134.85mM) |
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Ethanol |
40mg/mL (67.42mM) |
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Water |
Insoluble |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
1.6857mL |
8.4286mL |
16.8572mL |
5mM |
0.3371mL |
1.6857mL |
3.3714mL |
10mM |
0.1686mL |
0.8429mL |
1.6857mL |
生物活性
产品描述 |
一种非碘化胺碘酮衍生物,可抑制Na+,K+ and Ca2+的电流。 |
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靶点 |
Potassium Channel |
Autophagy |
体外研究 |
Dronedarone (SR-33589) is a multichannel blocker for atrial fibrillation.It is a potent inhibitor of the acetylcholine-activated K+ current from atrial and sinoatrial nodal tissue,and inhibits the rapid delayed rectifier more potently than slow and inward rectifier K+ currents and inhibits L-type calcium current. Under whole-cell patch clamp,it blocks IKr (IC50=3μM) and ICa-L (IC50=0.18μM).The effects on ICa-L are use- and frequency-dependent.Dronedarone inhibits current carried by human ether-ago-go gene (HERG)-expressing oocytes (analagous to IKr) with an IC50 of 9μM.In guinea pig ventricular myocytes,dronedarone exhibits a state dependent inhibition of the fast Na+ channel current with an IC50 of 0.7±0.1μM,when the holding potential is −80 mV. |
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体内研究 |
Dronedarone (Hydrochloride) reduces significantly the incidence of ventricular fibrillation (VF) from 80 to 30% (p<0.05) at 3mg/kg i.v.and eliminated VF and mortality at 10mg/kg i.v..Dronedarone inhibited carotid artery thrombus formation in vivo.Thrombin- and collagen-induced platelet aggregation is impaired indronedarone-treated mice (P\0.05),and expression ofplasminogen activator inhibitor-1 (PAI1),an inhibitor of the fibrinolytic system,is reduced in the arterial wall. |
推荐实验方法(仅供参考)
动物实验: |
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Rats:Rats are anesthetized,artificially ventilated,and the thorax opened by a left thoracotomy.Ischemia is induced by left coronary artery ligation,and reperfusion is achieved (after a 5-min period of ischemia) in a separate group of rats by removing the ligature.Agents are given intravenously 5 min before occlusion or orally 4h before study. Mice:Twelve-week-old C57Bl/6 mice are divided into two groups:dronedarone (200mg/kg body weight with a once daily oral gavage for 14 days) or control (1.4% methylcellulose). Twenty-four hours after the last application,mice are anesthetized by intraperitoneal injection of 87mg/kg sodium pentobarbital.Rose bengal is diluted to 12mg/mL in phosphate-buffered saline and then injected into the tail vein at a concentration of 63mg/kg. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )