中文名称: | Docebenone | ||||
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英文名称: | Docebenone | ||||
别名: | AA 861 | ||||
CAS No: | 80809-81-0 | 分子式: | C21H26O3 | 分子量: | 326.43 |
CAS No: | 80809-81-0 | ||||
分子式: | C21H26O3 | ||||
分子量: | 326.43 |
基本信息
产品编号:D10785 |
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产品名称:Docebenone |
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CAS: |
80809-81-0 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
六个月 |
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分子量 |
326.43 |
-20℃ |
一个月 |
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化学名: |
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Solubility (25°C) |
体外 |
DMSO |
77mg/mL (200.78mM) |
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Ethanol |
Insoluble |
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Water |
Insoluble |
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体内(现配现用) |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
3.0634mL |
15.3172mL |
30.6344mL |
5mM |
0.6127mL |
3.0634mL |
6.1269mL |
10mM |
0.3063mL |
1.5317mL |
3.0634mL |
生物活性
产品描述 |
一种有效的、选择性的和有口服活性的 5-脂氧合酶 (5-LO) 抑制剂。 |
靶点/IC50 |
5-LO |
体外研究 |
Treatment of trichomonads with the 5-LO inhibitor Docebenone,significantly inhibits the ability of trichomonads to secrete LTB4 compared to results for trichomonads treated with medium. Docebenone strongly abolishes the stimulatory effect of TvSP on IL-8 production. Docebenone at 10-200μM increases [Ca2+]i concentration dependently. |
体内研究 |
Docebenone might protect experimental acute necrotizing pancreatitis in rats.Docebenone suppresses the release of SRS-A by 55-97%, dose-dependently in doses of 10-8-10-5M in monkeys.The antigen-induced SRS-A release from these fragments is dose dependently inhibited by 25-93% of Docebenone, with doses of 10-8-10-5M. |
推荐实验方法(仅供参考)
动物实验: |
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Rats Pancreatitis is induced in rats by retrograde injection of 0.4mL/kg body wt of 6% taurocholic acid into the pancreatic duct.The animals are divided into three groups: control group;administered Docebenone in a single dose of 30mg/kg; and administered Docebenone in a single dose of 60mg/kg. The following parameters are examined: serum amylase, lipase,trypsin, blood sugar,and survival rate. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )