中文名称: | 地诺前列素氨丁三醇 | ||||
---|---|---|---|---|---|
英文名称: | Dinoprost tromethamine salt | ||||
别名: | 缓血酸胺盐 Prostaglandin F2α tromethamine salt; PGF2α THAM; Prostaglandin F2α THAM | ||||
CAS No: | 38562-01-5 | 分子式: | C24H45NO8 | 分子量: | 475.62 |
CAS No: | 38562-01-5 | ||||
分子式: | C24H45NO8 | ||||
分子量: | 475.62 | ||||
EINEC: | 254-002-3 | ||||
EINEC: | 254-002-3 |
基本信息
产品编号: |
D10753 |
||||
产品名称: |
Dinoprost tromethamine salt |
||||
CAS: |
38562-01-5 |
储存条件 |
粉末 |
-20℃ |
四年 |
|
|
||||
分子式: |
溶于液体 |
-80℃ |
6个月 |
||
分子量: |
475.62 |
-20℃ |
1个月 |
||
化学名: |
Prostaglandin F2α tromethamine salt |
||||
Solubility (25°C): |
|||||
体外:
|
DMSO |
95mg/mL (199.73mM) |
|||
Ethanol |
95mg/mL (199.73mM) |
||||
Water |
95mg/mL (199.73mM) |
||||
体内(现配现用): |
|
||||
<1mg/ml表示微溶或不溶。 |
|||||
普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
|||||
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
2.1025mL |
10.5126mL |
21.0252mL |
5mM |
0.4205mL |
2.1025mL |
4.2050mL |
10mM |
0.2103mL |
1.0513mL |
2.1025mL |
50mM |
0.0421mL |
0.2103mL |
0.4205mL |
生物活性
产品描述 |
一种口服有效的前列腺素 F (PGF) 受体 (FP receptor) 激动剂。 |
||
靶点 |
FP Receptor |
Human Endogenous Metabolite |
|
体外研究 |
Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt;1μM;for 24 hours) induces ER stress,autophagy,and apoptosis in goat luteal cells.Dinoprost tromethamine salt (1μM;for 24 hours) significantly increases the expression of GRP78 and UPR sensors. Apoptosis Analysis |
||
Cell Line: |
Goat luteal cells |
||
Concentration: |
1μM |
||
Incubation Time: |
For 24 hours |
||
Result: |
Significantly increased the apoptotic rate (15.62±3.12%). |
||
Cell Autophagy Assay |
|||
Cell Line: |
Goat luteal cells |
||
Concentration: |
1μM |
||
Incubation Time: |
For 24 hours |
||
Result: |
There was extensive overlap between LC3 and LAMP1 in luteal cells and autophagolysosomes were formed in goat luteal cells. |
||
Western Blot Analysis |
|||
Cell Line: |
Goat luteal cells |
||
Concentration: |
1μM |
||
Incubation Time: |
For 24 hours |
||
Result: |
The expression of GRP78 and UPR sensors including cleaved ATF6,phosphorylated-EIF2S1,EIF2S1,ATF4,phosphorylated-IRE1,autophagy-related protein LC3-II,and pro-apoptosis factor cleaved Caspase3 increased significantly in the cells. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )