中文名称: | Compound 48/80 trihydrochloride | ||||
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英文名称: | Compound 48/80 trihydrochloride | ||||
别名: | Compound 48/80 trihydrochloride Compound 48/80 trihydrochloride | ||||
CAS No: | 848035-21-2 | 分子式: | C32H48Cl3N3O3 | 分子量: | 629.1 |
CAS No: | 848035-21-2 | ||||
分子式: | C32H48Cl3N3O3 | ||||
分子量: | 629.1 |
基本信息
产品编号: |
C11246 |
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产品名称: |
Compound 48/80 trihydrochloride |
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CAS: |
848035-21-2 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
六个月 |
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分子量 |
629.10 |
-20℃ |
一个月 |
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化学名: |
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Solubility (25°C): |
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体外:
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DMSO |
25mg/mL(39.74mM;Need ultrasonic) |
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Ethanol |
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Water |
25mg/mL(39.74mM;Need ultrasonic) |
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体内(现配现用): |
1.请依序添加每种溶剂:10% DMSO→40% PEG300→5% Tween-80→45% saline Solubility:≥2.5mg/mL(3.97mM);Clear solution |
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此⽅案可获得≥2.5mg/mL(3.97mM,饱和度未知)的澄清溶液。以1mL⼯作液为例,取100μL25.0mg/mL的澄清DMSO储备液加到400μL PEG300中,混合均匀;向上述体系中加⼊50μL Tween-80,混合均匀;然后继续加⼊450μL⽣理盐⽔定容⾄1mL。 |
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2.请依序添加每种溶剂:10% DMSO→90% (20% SBE-β-CD in saline) Solubility:≥2.5mg/mL(3.97mM);Clear solution |
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此⽅案可获得≥2.5mg/mL(3.97mM,饱和度未知)的澄清溶液。以1mL⼯作液为例,取100μL25.0mg/mL的澄清DMSO储备液加到900μL20%的SBE-β-CD⽣理盐⽔⽔溶液中,混合均匀。 |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
1.5896mL |
7.9479mL |
15.8957mL |
5mM |
0.3179mL |
1.5896mL |
3.1791mL |
10mM |
0.1590mL |
0.7948mL |
1.5896mL |
生物活性
产品描述 |
一种N-甲基对甲氧基苯乙胺与甲醛缩合产物的混合物。Compound 48/80 trihydrochloride也是一种组胺(histamine)释放剂和肥大细胞(mast cell)脱颗粒剂。Compound 48/80 trihydrochloride抑制人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性。 |
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体外研究 |
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) inhibits both cytosolic and particulate phosphatidylinositolspecific phospholipase C activities with a similar efficiency; IC50 values are 2.1μg/ml (supernatant) and 5.0μg/ml (particulate fraction). The aggregation of human platelets induced by ADP and PAF-acether is inhibited by Compound 48/80 |
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体内研究 |
Compound 48/80 trihydrochloride (0.75mg/kg; i.p.; Killed after 0.5, 3 or 6 h) increases serum serotonin, histamine and corticosterone levels at 0.5 h, but their increases were reduced thereafter. Compound 48/80 trihydrochloride causes oxidative stress in rat adrenal gland through mast cell degranulation |
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Animal Model: |
7-week-old Wistar male rats (fasted for 24 hours) |
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Dosage: |
0.75mg/kg |
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Administration: |
Intraperitoneal injection; Killed after 0.5, 3 or 6 h |
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Result: |
Serum histamine and serotonin concentrations significantly higher than those in untreated control rats at 0.5 h after treatment. The increased serum histamine and serotonin concentrations in rats decreased time-dependently thereafter. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )