| 中文名称: | CHPG Sodium Salt | ||||
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| 英文名称: | CHPG Sodium Salt | ||||
| 别名: | CHPG Sodium Salt CHPG Sodium Salt | ||||
| CAS No: | 1303993-73-8 | 分子式: | C8H7ClNNaO3 | 分子量: | 223.59 |
| CAS No: | 1303993-73-8 | ||||
| 分子式: | C8H7ClNNaO3 | ||||
| 分子量: | 223.59 | ||||
基本信息
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产品编号： |
C11139 |
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产品名称： |
CHPG Sodium Salt |
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CAS: |
1303993-73-8 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
223.59 |
-20℃ |
1个月 |
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化学名： |
CHPG Sodium Salt |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
4.4725mL |
22.3624mL |
44.7247mL |
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5mM |
0.8945mL |
4.4725mL |
8.9449mL |
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10mM |
0.4472mL |
2.2362mL |
4.4725mL |
生物活性
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产品描述 |
一个选择性的mGluR5激动剂，并且通过TSG-6/NF-κB途径减弱BV2小神经胶质细胞SO2诱导的氧化应激和炎症。CHPGsodiumsalt通过ERK和Akt途径在体外和体内预防创伤性脑损伤(TBI)。 |
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靶点 |
mGlu5 |
NF-κBt |
ERK |
Akt |
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体外研究 |
CHPG sodium salt (10-500µM;24 hours) significantly increases the cell viability and decreases the LDH release after SO2 derivatives treatment.CHPG sodium salt (0.5mM;30 mins ) protects BV2 cells against SO2-induced apoptosis.CHPG sodium salt (0.5mM;30 mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels. Cell Viability Assay |
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Cell Line: |
BV2 microglial cells |
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Concentration: |
10,50,100 and 500µM |
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Incubation Time: |
24 hours |
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Result: |
Increased the cell viability. |
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Apoptosis Analysis |
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Cell Line: |
BV2 microglial cells |
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Concentration: |
0.5mM |
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Incubation Time: |
30 mins |
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Result: |
Protected BV2 cells against SO2-induced apoptosis. |
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Western Blot Analysis |
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Cell Line: |
BV2 microglial cells |
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Concentration: |
0.5mM |
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Incubation Time: |
30 mins |
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Result: |
Increased the expression of TSG-6 in both mRNA and protein levels. |
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体内研究 |
CHPG sodium salt (injection;250nM;for 7 days) reduces significantly cerebral lesion volume. |
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Animal Model: |
Adult Sprague-Dawley male rats weighing 280-320g |
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Dosage: |
250nM |
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Administration: |
Injection;for 7 days |
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Result: |
Reduced significantly cerebral lesion volume. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
