| 中文名称: | Calhex 231 hydrochloride | ||||
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| 英文名称: | Calhex 231 hydrochloride | ||||
| CAS No: | 2387505-78-2 | 分子式: | C25H28Cl2N2O | 分子量: | 443.41 |
| CAS No: | 2387505-78-2 | ||||
| 分子式: | C25H28Cl2N2O | ||||
| 分子量: | 443.41 | ||||
基本信息
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产品编号： |
C110990 |
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产品名称： |
Calhex 231 hydrochloride |
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CAS: |
2387505-78-2 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
443.41 |
-20℃ |
1个月 |
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化学名： |
4-chloro-N-[(1S,2S)-2-[[(1R)-1-naphthalen-1-ylethyl]amino]cyclohexyl]benzamide;hydrochloride |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.2552mL |
11.2762mL |
22.5525mL |
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5mM |
0.4510mL |
2.2552mL |
4.5105mL |
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10mM |
0.2255mL |
1.1276mL |
2.2552mL |
生物活性
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产品描述 |
一种通过负变构调节来抑制 CaSR的。Calhex 231 hydrochloride 在 HEK293 细胞中阻断 Ca2+诱导的肌醇磷酸酯的积累，IC50为0.39μM。Calhex 231 hydrochloride 可用于糖尿病性心肌病 (DCM) 的研究。 |
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靶点 |
CaSR IC50:0.39μM (Inositol phosphate) |
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体外研究 |
Calhex231 treatment significantly decreases the proliferation of cardiac fibroblasts.Calhex231 treatment significantly downregulates the CaSR,α-SMA,Col-I/III,MMP2/9 expresses.Calhex231 alleviates high glucose-induced myocardial fibrosis in cardiac fibroblasts.Calhex 231 could inhibit Itch (atrophin-1 interacting protein 4)-ubiquitin proteasome and TGF-β1/Smads pathways,and then depress the proliferation of cardiac fibroblasts,along with the reduction deposition of collagen, alleviate glucose-induced myocardial fibrosis. Cell Proliferation Assay |
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Cell Line: |
Primary neonatal rat cardiac fibroblasts (CFs) |
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Concentration: |
3µM |
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Incubation Time: |
24 hours |
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Result: |
Significantly decreased the proliferation of cardiac fibroblasts. |
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Western Blot Analysis |
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Cell Line: |
Primary neonatal rat cardiac fibroblasts (CFs) |
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Concentration: |
3µM |
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Incubation Time: |
48 hours |
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Result: |
The expression of CaSR,α-SMA,Col-I/III,MMP2/9 were significantly downregulated. |
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体内研究 |
Calhex 231 (4.07mg/kg (10µmol/kg);intraperitoneal injection;daily;for 12 weeks;male Wistar rats) treatment ameliorates diabetic myocardial fibrosis in type 1 diabetic model (T1D) rats. |
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Animal Model: |
Male Wistar rats (8 weeks old) injected with Streptozotocin |
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Dosage: |
4.07mg/kg (10µmol/kg) |
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Administration: |
Intraperitoneal injection;daily;for 12 weeks |
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Result: |
Ameliorated diabetic myocardial fibrosis in T1D rats. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
