中文名称: | Cardiogenol C HCL | ||||
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英文名称: | Cardiogenol C HCL | ||||
别名: | Wnt 4-(2-Hydroxyethylamino)-2-(4-methoxyphenylamino)-pyrimidine hydrochloride | ||||
CAS No: | 671225-39-1 | 分子式: | C13H16N4O2.HCl | 分子量: | 296.75 |
CAS No: | 671225-39-1 | ||||
分子式: | C13H16N4O2.HCl | ||||
分子量: | 296.75 |
基本信息
产品编号: |
C10392 |
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产品名称: |
Cardiogenol C HCL |
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CAS: |
671225-39-1 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
两年 |
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分子量 |
296.75 |
-20℃ |
1个月 |
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化学名: |
4-(2-Hydroxyethylamino)-2-(4-methoxyphenylamino)-pyrimidine hydrochloride |
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Solubility (25°C): |
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体外:
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DMSO |
≥ 55mg/mL (185.34mM) |
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Water |
2 mg/mL (6.74mM; Need ultrasonic) |
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Ethanol |
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体内(现配现用): |
1.请依序添加每种溶剂: 10% DMSO→40% PEG300→5% Tween-80→45% saline Solubility: 2.5 mg/mL (8.42mM); Clear solution; Need ultrasonic |
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此方案可获得 2.5 mg/mL (8.42mM) 的澄清溶液。 以 1mL 工作液为例,取 100μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400μL PEG300 中,混合均匀;向上述体系中加入50μL Tween-80,混合均匀;然后继续加入 450μL生理盐水定容至 1mL。 |
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2.请依序添加每种溶剂: 10% DMSO→90% (20% SBE-β-CD in saline) Solubility: ≥ 2.5 mg/mL (8.42mM); Clear solution |
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此方案可获得 ≥ 2.5 mg/mL (8.42mM,饱和度未知) 的澄清溶液。 以 1mL 工作液为例,取 100μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。 |
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3.请依序添加每种溶剂: 10% DMSO→90% corn oil Solubility: ≥ 2.5 mg/mL (8.42mM); Clear solution |
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此方案可获得 ≥ 2.5 mg/mL (8.42mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。 以 1mL 工作液为例,取 100μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900μL玉米油中,混合均匀。 |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
3.3698mL |
16.8492mL |
33.6984mL |
5mM |
0.6740mL |
3.3698mL |
6.7397mL |
10mM |
0.3370mL |
1.6849mL |
3.3698mL |
生物活性
产品描述 |
一种二氨基嘧啶化合物,可诱导MHC阳性心肌细胞与胚胎干细胞分化,EC50:0.1μM。 |
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靶点 |
EC50: 100nM (differentiation of ESCs into cardiomyocytes) |
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体外研究 |
Cardiogenol C hydrochloride (1μM; 7 days) has a cardiomyogenic effect on P19 cells, it significantly increases atrial natriuretic factor (ANF, nppa) in P19 cells when it compares to untreated control cells. Cardiogenol C hydrochloride (0.01-100μM; 7 days) significantly increases ANF expression. In addition, another frequently used cardiac marker gene (NKX2-5) is also significantly increased by this small molecule in C2C12 cells. Cardiogenol C hydrochloride (0.001-100μM; 7 days) increases cardiac Nav1.5 sodium channel protein expression as dosedependent manner in C2C12 cells. Cardiogenol C hydrochloride (1μM; 35 days) addition from day 0 significantly increases myocardial differentiation and results in a significantly increased percentage of CBs with beating cardiomyocytes. This small moleculepromotes the development of beating cardiomyocytes in cardiovascular progenitor cell-derived cardiac bodies . Cardiogenol C hydrochloride (0.01-100μM; 7 days) does not effect cell growth even at 10μM. In addition, Cardiogenol C either solves in water or DMSO generates a similar effect. The highest concentration, 100μM has significant cellular toxicity on C2C12 cells. RT-PCR |
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Cell Line: |
C2C12 cells |
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Concentration: |
0.01μM; 0.1μM; 1μM; 3μM; 10μM; 30μM; 100μM |
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Incubation Time: |
7 days |
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Result: |
Increased ANF and NKX2.5 mRNA level as a dose-dependent manner. |
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Western Blot Analysis |
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Cell Line: |
C2C12 cells |
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Concentration: |
0.001μM; 0.01μM; 0.1μM; 1μM; 10μM |
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Incubation Time: |
7 days |
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Result: |
Increased cardiac Nav1.5 sodium channel protein levels. |
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Cell Proliferation Assay |
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Cell Line: |
C2C12 cells |
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Concentration: |
0.01μM; 0.1μM; 1μM |
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Incubation Time: |
7 days |
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Result: |
Did not exert toxic effects on C2C12 cells at 0.01-10μM treatment. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )