中文名称: 壳聚糖
英文名称: Chitosan
CAS No: 9012-76-4
分子式: (C6H11NO4)N
EINEC: 9144
C10383 壳聚糖 脱乙酰基度≥85%,粘度:20-300mPa.s (psaitong)
包装规格:
100g 500g in poly bottle
溶解性:
溶于稀酸。
产品描述:

基本信息

产品编号:

C10383

产品名称:

Chitosan

CAS:

9012-76-4

 

储存条件

粉末

室温

四年

 

 

分子式:

(C6H11NO4)N

溶于液体

-80℃

六个月

分子量

 

-20℃

一个月

化学名: 

beta-1,4-Poly-delta-glucosamine

 

生物活性

产品描述

絮凝剂、蛋白沉淀剂、包裹剂和水性增稠剂。

靶点

 

体外研究

Chitosan (2mg/mL; 48 hours; SKMEL28 and RPMI7951 cells) treatment presents a reduced growth potential.

Chitosan (2mg/mL; 48 hours; RPMI7951 cells) treatment shows potent pro-apoptotic effects against RPMI7951 through the mitochondrial pathway.

Chitosan (2mg/mL; 48 hours; RPMI7951 cells) treatment induces an up regulation of pro-apoptotic molecules such as Bax and a down regulation of anti-apoptotic proteins like Bcl-2 and Bcl-XL.

Low-molecular-weight chitosan can penetrate bacterial cell walls, bind with DNA and inhibit DNA transcription and mRNA synthesis, while high-molecular-weight Chitosan can bind to the negatively charged components on the bacterial cell wall. It forms an impermeable layer around the cell, changes cell permeability and blocks transport into the cell. Chitosan also can be used in water treatment, wound-healing materials, pharmaceutical excipient or drug carrier, obesity research and as a scaffold for tissue engineering

Cell Viability Assay

Cell Line:

SKMEL28 and RPMI7951 cells

Concentration:

2mg/mL

Incubation Time:

48 hours

Result:

Presented a reduced growth potential.

Apoptosis Analysis

Cell Line:

RPMI7951 cells

Concentration:

2mg/mL

Incubation Time:

48 hours

Result:

Had potent pro-apoptotic effects against RPMI7951.

Western Blot Analysis

Cell Line:

RPMI7951 cells

Concentration:

2mg/mL

Incubation Time:

48 hours

Result:

Induced an up regulation of pro-apoptotic molecules such as Bax and a down regulation of anti-apoptotic proteins like Bcl-2 and Bcl-XL.

体内研究

In chemical-induced colonic precancerous lesions in ICR mice, in the 2 weeks preventive experiments, mice fed with a diet containing high molecular weight Chitosan (HMWC) had significant fewer aberrant crypt foci formation than those fed with control diet. As the treatment extended to 6 weeks, both low molecular weight Chitosan (LMWC)- and HMWC-fed mice contained less aberrant crypt foci when compared to control

保存条件:
室温
UN码:
HazardClass:
危害声明:
安全说明:
搜索质检报告(COA)
参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • =
    *
    *
    *选择对应的单位 *空出希望得到的变量,填写另外两个变量

用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )

  • * = *

连续稀释计算器方程

  • 连续稀释

  • 初始浓度:
  • 稀释倍数:
  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):