| 中文名称: | 二硫酸氯吡格雷 | ||||
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| 英文名称: | Clopidogrel Bisulfate | ||||
| 别名: | 氯吡格雷硫酸盐 (S)-(+)-Clopidogrel Sulfate | ||||
| CAS No: | 120202-66-6 | 分子式: | C16H16ClNO2S.H2SO4 | 分子量: | 419.89 |
| CAS No: | 120202-66-6 | ||||
| 分子式: | C16H16ClNO2S.H2SO4 | ||||
| 分子量: | 419.89 | ||||
| MDL: | MFCD00876395 | ||||
基本信息
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产品编号： |
C10129 |
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产品名称： |
Clopidogrel Bisulfate |
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CAS: |
120202-66-6 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
419.89 |
-20℃ |
1个月 |
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化学名： |
(S)-(+)-Clopidogrel Sulfate |
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Solubility (25°C)： |
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体外:
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DMSO |
83mg/mL (197.66mM) |
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Ethanol |
83mg/mL (197.66mM) |
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Water |
84mg/mL warmed with 50ºC water bath (200.04mM) |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.3815mL |
11.9076mL |
23.8152mL |
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5mM |
0.4763mL |
2.3815mL |
4.7630mL |
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10mM |
0.2382mL |
1.1908mL |
2.3815mL |
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50mM |
0.0476mL |
0.2382mL |
0.4763mL |
生物活性
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产品描述 |
一种P2Y12受体抑制剂。 |
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靶点 |
CYP2B6 18.2nM (IC50) |
CYP2C19 524nM (IC50) |
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体外研究 |
Clopidogrel (1.5mM;12 and 24 hours) up-regulates the expression of TRIB3 and CHOP in a concentration-and timedependent manner,as measured by real-time PCR and Western blot analysis.Clopidogrel (1.5mM;24 hours) significantly induces human gastric epithelial cell (GES-1) apoptosis. Western Blot Analysis |
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Cell Line: |
GES-1 cells |
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Concentration: |
1.5mM |
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Incubation Time: |
12 and 24 hours |
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Result: |
The mRNA expression levels of both CHOP and TRIB3 were up-regulated in a concentration- and time-dependent manner.The protein expression levels of both CHOP and TRIB3 were up-regulated in a concentration-and time-dependent manner. |
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Apoptosis Analysis |
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Cell Line: |
Gastric epithelial cell (GES-1) cells |
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Concentration: |
1.5mM |
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Incubation Time: |
24 hours |
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Result: |
Induced apoptosis of gastric epithelial cells． |
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体内研究 |
Clopidogrel (5mg/kg) significantly inhibits thrombus formation compared with vehicle.Acetylsalicylic acid (0.15mg/kg) can add to the antithrombotic effect of Clopidogrel in mice;Acetylsalicylic acid (0.6mg/kg) blunts the antithrombotic effect of Clopidogrel. |
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Animal Model: |
Age-matched C57BL/6J male mice weighing at least 25g were used at 8 to 12 weeks of age. |
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Dosage: |
5mg/kg |
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Administration: |
Gavage treatment |
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Result: |
Clopidogrel significantly inhibited thrombus formation compared with vehicle.When Clopidogrel was given in combination with 0.6mg/kg ASA,thrombi were significantly larger than those measured with Clopidogrel alone.In contrast,when Clopidogrel was given in combination with 0.15mg/kg ASA,thrombi were significantly smaller than those in mice treated with Clopidogrel and 0.6mg/kg ASA,and smaller than those in mice given Clopidogrel alone. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
