中文名称: | CNQX 促销 | ||||
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英文名称: | CNQX | ||||
别名: | 6-氰基-7-硝基喹喔啉-2,3-二酮 6-Cyano-7-nitroquinoxaline-2,3-dione FG9065 1,4-dihydro-2,3-dihydroxy-7-nitro-6-quinoxalinecarbonitrile | ||||
CAS No: | 115066-14-3 | 分子式: | C9H4N4O4 | 分子量: | 232.15 |
CAS No: | 115066-14-3 | ||||
分子式: | C9H4N4O4 | ||||
分子量: | 232.15 | ||||
MDL: | MFCD00069232 |
基本信息
产品编号: |
C10090 |
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产品名称: |
CNQX |
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CAS: |
115066-14-3 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
232.15 |
-20℃ |
1个月 |
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化学名: |
6-Cyano-7-nitroquinoxaline-2,3-dione FG9065 1,4-dihydro-2,3-dihydroxy-7-nitro-6-quinoxalinecarbonitrile |
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Solubility (25°C): |
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体外:
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DMSO |
46mg/mL (198.14mM) |
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Ethanol |
Insoluble |
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Water |
Insoluble |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
4.3076mL |
21.5378mL |
43.0756mL |
5mM |
0.8615mL |
4.3076mL |
8.6151mL |
10mM |
0.4308mL |
2.1538mL |
4.3076mL |
生物活性
产品描述 |
一种具有竞争性的AMPA/kainate受体拮抗剂。 |
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靶点 |
IC50:0.3μM (AMPA)and 1.5μM (kainate receptor) |
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体外研究 |
CNQX (FG9065;2-5μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP),while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices.CNQX (1-5μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments. |
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体内研究 |
CNQX (FG9065;2-5μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP),while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices.CNQX (1-5μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments. |
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Animal Model: |
Male Wistar rats weighing 180-200g |
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Dosage: |
0.75,1.5,and 3mg/kg |
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Administration: |
IP;20 min before testing |
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Result: |
Decreased the number of cocaine (IV;0.25 mg/infusion) responses in a dose-dependent manner during the first 15-min cocaine-free interval |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )