β-丁香烯 - CAS:87-44-5 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	β-丁香烯促销
英文名称:	β-Caryophyllene
别名:	(-)-反式石竹烯 Caryophyllene
CAS No:	87-44-5	分子式:	C₁₅H₂₄	分子量:	204.35
CAS No:	87-44-5
分子式:	C₁₅H₂₄
分子量:	204.35
MDL:	MFCD00075925

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C10088 β-丁香烯 90% (psaitong)

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沸点：

129-130°C

密度：

0.901g/mL

外观与性状：

淡黄色液体

包装规格：

100ml 500ml in glass bottle

产品描述：

基本信息

产品编号：	C10088
产品名称：	β-Caryophyllene
CAS:	87-44-5	储存条件	粉末	室温	四年

分子式：	C15H24		溶于液体	-20℃	两年
分子量	204.35
化学名：	(1R,4E,9S)-4,11,11-trimethyl-8-methylidenebicyclo[7.2.0]undec-4-ene
Solubility (25°C)：
体外:	DMSO	100mg/mL (489.36mM; Need ultrasonic)
	Ethanol	≥ 176.67mg/mL (864.55mM)
	Water	< 0.1mg/mL (insoluble)
体内(现配现用):	1.请依序添加每种溶剂：10% EtOH→40% PEG300→5% Tween-80→45% saline Solubility: ≥ 13.25mg/mL (64.84mM); Clear solution
	此⽅案可获得 ≥ 13.25mg/mL (64.84mM，饱和度未知) 的澄清溶液。以 1mL ⼯作液为例，取 100μL 132.5mg/mL 的澄清 EtOH 储备液加到 400μL PEG300 中，混合均匀；向上述体系中加⼊ 50μL Tween-80，混合均匀；然后继续加⼊ 450μL ⽣理盐⽔定容⾄ 1mL。
	2.请依序添加每种溶剂：10% EtOH→90% (20% SBE-β-CD in saline) Solubility: 13.25mg/mL (64.84mM); Suspended solution; Need ultrasonic
	此⽅案可获得 13.25mg/mL (64.84mM) 的均匀悬浊液，悬浊液可⽤于⼝服和腹腔注射。以 1mL ⼯作液为例，取 100μL 132.5mg/mL 的澄清 EtOH 储备液加到 900μL 20% 的 SBE-β-CD ⽣理盐⽔⽔溶液中，混合均匀。
	3.请依序添加每种溶剂：10% EtOH→90% corn oil Solubility: ≥ 13.25mg/mL (64.84mM); Clear solution
	此⽅案可获得 ≥ 13.25mg/mL (64.84mM，饱和度未知) 的澄清溶液，此⽅案不适⽤于实验周期在半个⽉以上的实验。以 1mL ⼯作液为例，取 100μL 132.5mg/mL 的澄清 EtOH 储备液加到 900μL ⽟⽶油中，混合均匀。
	4.请依序添加每种溶剂：10% DMSO→40% PEG300→5% Tween-80→45% saline Solubility: ≥ 2.5mg/mL (12.23mM); Clear solution
	此⽅案可获得 ≥ 2.5mg/mL (12.23mM，饱和度未知) 的澄清溶液。以 1mL ⼯作液为例，取 100μL 25.0mg/mL 的澄清 DMSO 储备液加到 400μL PEG300 中，混合均匀；向上述体系中加⼊ 50 μ L Tween-80，混合均匀；然后继续加⼊ 450μL ⽣理盐⽔定容⾄ 1mL。
	5.请依序添加每种溶剂：10% DMSO→90% (20% SBE-β-CD in saline) Solubility: 2.5mg/mL (12.23mM); Suspended solution; Need ultrasonic
	此⽅案可获得 2.5mg/mL (12.23mM) 的均匀悬浊液，悬浊液可⽤于⼝服和腹腔注射。以 1mL ⼯作液为例，取 100μL 25.0mg/mL 的澄清 DMSO 储备液加到 900μL 20% 的 SBE-β-CD ⽣理盐⽔⽔溶液中，混合均匀。
	6.请依序添加每种溶剂：10% DMSO→90% corn oil Solubility: ≥ 2.5mg/mL (12.23mM); Clear solution
	此⽅案可获得 ≥ 2.5mg/mL (12.23mM，饱和度未知) 的澄清溶液，此⽅案不适⽤于实验周期在半个⽉以上的实验。以 1mL ⼯作液为例，取 100μL 25.0mg/mL 的澄清 DMSO 储备液加到 900μL ⽟⽶油中，混合均匀。
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	4.8936mL	24.4678mL	48.9356mL
5mM	0.9787mL	4.8936mL	9.7871mL
10mM	0.4894mL	2.4468mL	4.8936mL

生物活性

产品描述	一种非变性离子洗涤剂,于提取膜蛋白。
靶点	Human Endogenous Metabolite
体外研究	Among the tested cancer cells, β-Caryophyllene demonstrates selective anti-proliferative effect against three cancer cell lines, namely HCT 116 (colon cancer, IC50=19μM), PANC-1 (pancreatic cancer, IC50=27μM), and HT29 (colon cancer, IC50=63μM) cells, whereas β-Caryophyllene exhibits either moderate or poor cytotoxic effects against ME-180, PC3, K562 and MCF-7. Results show that β-Caryophyllene possesses higher selectivity towards the colorectal cancer cells (HCT 116), with selectivity index (SI)=27.9, followed by PANC-1 and HT 29 cells with SI=19.6 and 8, respectively. The apoptotic index estimated for β-Caryophyllene treatment on HCT 116 cells after 24 h treatment is 64±0.04. β-Caryophyllene at 10μM concentration, causes significant nuclei condensation after 6 h of treatment. β-caryophyllene exhibits a dose and timedependent inhibitory effect on the motility of HCT 116 cells
体内研究	Treatment with β-Caryophyllene at different doses does not show any effects on swimming speed during the test. Oral treatment with β-Caryophyllene ameliorates the rise in β-amyloid deposition in the transgenic mice in a roughly dosedependent manner, and the two higher doses exhibit almost equal effects in modifying the β-amyloid burden. The number of activated astroglial cells is higher in vehicle-treated mouse brains than in β-Caryophyllene-treated mouse brains with different doses. β-Caryophyllene is effective at reducing the enhancement of the COX-2 protein level found in vehicle-treated APP/PS1 mice[1]. Animals treated with β-Caryophyllene display higher values of object recognition index than their vehicle-treated counterparts [t(14)=4.204, P<0.05]. The total time spent in object exploration during the test trial is not significantly different between β-Caryophyllene-treated and vehicle-treated animals (t(14)=0.5874, P>0.05). Treatment with βCaryophyllene does not significantly alter these seizure-induced neurochemical changes

推荐实验方法(仅供参考)

Cell Assay	Panel of human cancer cells such as, pancreatic (PANC-1), colorectal (HCT-116 and HT-29), invasive squamous cell carcinoma (ME-180), leukemia (K562), hormone sensitive and invasive breast cancer cell line (MCF-7), and prostatic (PC3) adenocarcinoma cell lines are used. Cells are incubated in a humidified CO2 incubator at 37°C supplied with 5% CO2. Inhibitory effect of β-Caryophyllene on proliferation of the cell lines is tested using the MTT assay. The selectivity index (SI) for the cytotoxicity of β-Caryophyllene is calculated using the ratio of IC50 of β-Caryophyllene on a normal cell line (NIH-3T3) to the IC50 of β-Caryophyllene on cancer cell lines

Animal Administration	Male double transgenic APP/PS1 mice and wild-type littermates are used. The mice are group housed (3 to 5 animals/cage) with a 12:12-hour light/dark cycle and ad libitum access to food and water. In this experiment, animals are orally treated by gavage with 16, 48, or 144mg/kg of β-Caryophyllene every morning for 10 weeks starting at the age of 7 months. All vehicle solutions are used for the respective control animal treatments and the Morris water maze test is performed

保存条件：

室温

UN码：

HazardClass：

危害声明：

安全说明：

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参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量 =

浓度 *

体积 *

分子量

*选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )

* = *

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

摩尔浓度计算公式

稀释公式

连续稀释计算器方程

连续稀释

计算结果