| 中文名称: | Biricodar | ||||
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| 英文名称: | Biricodar | ||||
| 别名: | 比立考达 VX-710 | ||||
| CAS No: | 159997-94-1 | 分子式: | C34H41N3O7 | 分子量: | 603.71 |
| CAS No: | 159997-94-1 | ||||
| 分子式: | C34H41N3O7 | ||||
| 分子量: | 603.71 | ||||
基本信息
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产品编号： |
B11340 |
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产品名称： |
Biricodar |
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CAS: |
159997-94-1 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
四年 |
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分子量： |
603.71 |
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化学名： |
1,7-dipyridin-3-ylheptan-4-yl(2S)-1-[2-oxo-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylate |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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生物活性
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产品描述 |
P-glycoprotein和MRP-1的调节剂;在多药耐药细胞中显示出有效的化学敏化活性。 |
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靶点 |
P-glycoprotein |
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体外研究 |
Biricodar shows activity against both P-glycoprotein (Pgp) and MRP-1 and also has activity in increasing drug uptake and retention and reversing drug resistance mediated by wild-type BCRP (BCRPR482).In 8226/Dox6 cells (Pgp),biricodar increases mitoxantrone and daunorubicin uptake by 55 and 100%,respectively,increases their retention by 100 and 60%,respectively,and increases their cytotoxicity 3.1- and 6.9-fold,respectively.Biricodar also increases the uptake,retention and cytotoxicity in HL60/Adr (MRP-1) and 8226/MR20 cells (BCRP(R482)),but has little effect in MCF7 AdVP3000 cells (BCRP(R482T)).VX-710 is a non-macrocyclic pipecolinate derivative which binds the FK506 receptor protein.VX-710 has been shown to restore sensitivity in a range of multidrug-resistant cells,including myeloma,melanoma,carcinoma and leukaemia.Biricodar effectively inhibits photoaffinity labeling of P-glycoprotein by [3H]azidopine or [125I]iodoaryl azidoprazosin with EC50 values of 0.75 and 0.55μM. |
推荐实验方法(仅供参考)
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细胞实验: |
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To study cytotoxicity in suspension cell lines,cells are plated in 96-well tissue culture plates at a density of 10,000 cells/well in RPMI 1640 supplemented with 10% FCS,2mM l-glutamine,20 units/mL penicillin,and 20μg/mL streptomycin.Drug is added to the culture medium to achieve final concentrations of 0.3nM to 10μM,with half-log increments, with and without biricodar at a final concentration of 2.5μM.The final volume of medium per well is 100μL.Cells are incubated for 96 h at 37℃ in a fully humidified atmosphere of 5% CO2 in air.Cell growth is assessed by the WST-1 colorimetric assay. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
