中文名称: BRD7389
英文名称: BRD7389
CAS No: 376382-11-5
分子式: C24H18N2O2
分子量: 366.41
B11309 BRD7389 ≥98% (psaitong)
包装规格:
5mg in glass bottle
产品描述:

基本信息

产品编号:

B11309

产品名称:

BRD7389

CAS:

376382-11-5

 

储存条件

粉末

-20℃

四年

 

 

分子式:

C24H18N2O2

溶于液体

-80℃

六个月

分子量

366.41

-20℃

一个月

化学名: 

2-hydroxy-1-(phenethylamino)-7H-naphtho[1,2,3-de]quinolin-7-one

 

生物活性

产品描述

一种特异性的RSK家族激酶抑制剂,可以诱导胰腺α细胞中胰岛素表达。

靶点

RSK1

1.5μM(IC50)

RSK2

2.4μM(IC50)

RSK3

1.2μM(IC50)

CDK5/p35

6.5μM(IC50)

DRAK1

2.8μM(IC50)

FLT3

3.5μM(IC50)

PIM1

3.7μM(IC50)

PKG1α

6.5μM(IC50)

SGK

13.8μM(IC50)

 

体外研究

BRD7389 (0.425-6.8μM) induces insulin expression in mouse α-cells after 3 days treatment. BRD7389 induces a dosedependent up-regulation of insulin (Ins2) mRNA, peaking at 0.85μM; 5 days treatment with BRD7389 results in greater induction of insulin gene expression, about 50-fold at 0.85μM.

BRD7389 (0.85-6.8μM) significantly up-regulates Pdx1 mRNA expression in mouse α-cell line.

BRD7389 also increases β-cell-specific gene expression in primary human islet cells.

BRD7389 (1μM; added 30 min prior to Carbachol treatment 48 h) fully abolishes carbachols timulated cell proliferation, but has little effect on the basal level of proliferation

RT-PCR

Cell Line:

Mouse α-cell line

Concentration:

0.425, 0.85, 1.7, 3.4, 6.8μM

Incubation Time:

3 days and 5 days

Result:

Up-regulated expression of Pdx1.

Cell Proliferation Assay

Cell Line:

SNU-407 colon cancer cell

Concentration:

1μM

Incubation Time:

Added 30 min prior to Carbachol treatment (48 h)

Result:

Almost completely blocked Carbachol (1mM)-stimulated cell proliferation.

保存条件:
-20℃
UN码:
HazardClass:
危害声明:
安全说明:
搜索质检报告(COA)
参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

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用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )

  • * = *

连续稀释计算器方程

  • 连续稀释

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  • 稀释倍数:
  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):