中文名称: bpV(phen) trihydrate
英文名称: bpV(phen) trihydrate
CAS No: 171202-16-7
分子式: C12H14KN2O8V
分子量: 404.29
B10635 bpV(phen) trihydrate ≥98% (psaitong)
包装规格:
10mg in glass bottle
产品描述:

基本信息

产品编号:B10635

产品名称:bpV(phen) trihydrate

CAS:

171202-16-7

 

储存条件

粉末

2-8℃

四年

 

 

分子式:

C12H14KN2O8V

溶于液体

-80℃

六个月

分子量

404.29

-20℃

一个月

化学名: 

 

 

Solubility (25°C)

 

体外

DMSO

 

Ethanol

 

Water

18mg/mL (44.52mM Need ultrasonic)

体内

现配现用

 

1mg/ml表示微溶或不溶。

普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。

 

 

制备储备液

 

浓度

 

溶液体积

质量

 

1mg

 

5mg

 

10mg

1mM

2.4735mL

12.3674mL

24.7347mL

5mM

0.4947mL

2.4735mL

4.9469mL

10mM

0.2473mL

1.2367mL

2.4735mL

 

 

生物活性

产品描述

一种胰岛素模拟物,是一种有效的蛋白酪氨酸磷酸酶 (PTP) 和 PTEN 抑制剂,对 PTEN,PTP-β 和 PTP-1B 的 IC50 为 38nM,343nM 和 920nM。

靶点/IC50

PTEN

IC50: 38nM

PTP-β

343nM

PTP-1B

920nM

Parasite Leishmania

Apoptosis

 

体外研究

bpV(phen) (5μM; 24.5 hours; H9c2 cells) treatment causes a further decrease of cell viability in H/R-injured H9c2 cells. bpV(phen) (5μM; 24.5 hours; H9c2 cells) treatment increases the apoptosis of H/R-injured H9c2 cells.bpV(phen) (5μM; 24.5 hours; H9c2 cells) treatment significantly promotes the accumulation of cytoplasmic Cytochrome C inH/R-injured H9c2 cells.After stimulation of bpV(phen), PTEN-induced putative kinase protein 1 (PINK1)/Parkin-mediated mitophagy is inhibited.bpV(phen) is an insulin-mimetic agent following insulin-receptor tyrosine kinase hyperphosphorylation and activation.

Cell Viability Assay

Cell Line:

Hypoxia/reoxygenation (H/R)-injured H9c2 cells

Concentration:

5μM

Incubation Time:

24.5 hours (hypoxia for 24h; reoxygenation for 30 minutes)

Result:

Caused a further decrease of cell viability.

Apoptosis Analysis

Cell Line:

Hypoxia/reoxygenation (H/R)-injured H9c2 cells

Concentration:

5μM

Incubation Time:

24.5 hours (hypoxia for 24h; reoxygenation for 30 minutes)

Result:

Increased the apoptosis of H/R-injured H9c2 cells.

Western Blot Analysis

Cell Line:

Hypoxia/reoxygenation (H/R)-injured H9c2 cells

Concentration:

5μM

Incubation Time:

24.5 hours (hypoxia for 24h; reoxygenation for 30 minutes)

Result:

Showed an increased release of Cytochrome C.

体内研究

bpV(phen) (5mg/kg; intraperitoneal injection; daily; for 38 days; male BALB/c nude (nu/nu) athymic mice) treatment causes a significant reduction in average tumor volume.

Animal Model:

Male BALB/c nude (nu/nu) athymic mice (6-7 weeks old) injected with PC-3 cells

Dosage:

5mg/kg

Administration:

Intraperitoneal injection; daily; for 38 days

Result:

Caused a significant reduction in average tumor volume.

保存条件:
2-8℃
UN码:
HazardClass:
危害声明:
安全说明:
搜索质检报告(COA)
参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • =
    *
    *
    *选择对应的单位 *空出希望得到的变量,填写另外两个变量

用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )

  • * = *

连续稀释计算器方程

  • 连续稀释

  • 初始浓度:
  • 稀释倍数:
  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):