中文名称: | bpV(phen) trihydrate | ||||
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英文名称: | bpV(phen) trihydrate | ||||
CAS No: | 171202-16-7 | 分子式: | C12H14KN2O8V | 分子量: | 404.29 |
CAS No: | 171202-16-7 | ||||
分子式: | C12H14KN2O8V | ||||
分子量: | 404.29 |
基本信息
产品编号:B10635 |
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产品名称:bpV(phen) trihydrate |
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CAS: |
171202-16-7 |
储存条件 |
粉末 |
2-8℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
六个月 |
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分子量 |
404.29 |
-20℃ |
一个月 |
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化学名: |
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Solubility (25°C) |
体外 |
DMSO |
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Ethanol |
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Water |
18mg/mL (44.52mM Need ultrasonic) |
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体内 |
现配现用 |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
2.4735mL |
12.3674mL |
24.7347mL |
5mM |
0.4947mL |
2.4735mL |
4.9469mL |
10mM |
0.2473mL |
1.2367mL |
2.4735mL |
生物活性
产品描述 |
一种胰岛素模拟物,是一种有效的蛋白酪氨酸磷酸酶 (PTP) 和 PTEN 抑制剂,对 PTEN,PTP-β 和 PTP-1B 的 IC50 为 38nM,343nM 和 920nM。 |
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靶点/IC50 |
PTEN IC50: 38nM |
PTP-β 343nM |
PTP-1B 920nM |
Parasite Leishmania |
Apoptosis |
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体外研究 |
bpV(phen) (5μM; 24.5 hours; H9c2 cells) treatment causes a further decrease of cell viability in H/R-injured H9c2 cells. bpV(phen) (5μM; 24.5 hours; H9c2 cells) treatment increases the apoptosis of H/R-injured H9c2 cells.bpV(phen) (5μM; 24.5 hours; H9c2 cells) treatment significantly promotes the accumulation of cytoplasmic Cytochrome C inH/R-injured H9c2 cells.After stimulation of bpV(phen), PTEN-induced putative kinase protein 1 (PINK1)/Parkin-mediated mitophagy is inhibited.bpV(phen) is an insulin-mimetic agent following insulin-receptor tyrosine kinase hyperphosphorylation and activation. Cell Viability Assay |
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Cell Line: |
Hypoxia/reoxygenation (H/R)-injured H9c2 cells |
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Concentration: |
5μM |
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Incubation Time: |
24.5 hours (hypoxia for 24h; reoxygenation for 30 minutes) |
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Result: |
Caused a further decrease of cell viability. |
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Apoptosis Analysis |
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Cell Line: |
Hypoxia/reoxygenation (H/R)-injured H9c2 cells |
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Concentration: |
5μM |
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Incubation Time: |
24.5 hours (hypoxia for 24h; reoxygenation for 30 minutes) |
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Result: |
Increased the apoptosis of H/R-injured H9c2 cells. |
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Western Blot Analysis |
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Cell Line: |
Hypoxia/reoxygenation (H/R)-injured H9c2 cells |
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Concentration: |
5μM |
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Incubation Time: |
24.5 hours (hypoxia for 24h; reoxygenation for 30 minutes) |
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Result: |
Showed an increased release of Cytochrome C. |
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体内研究 |
bpV(phen) (5mg/kg; intraperitoneal injection; daily; for 38 days; male BALB/c nude (nu/nu) athymic mice) treatment causes a significant reduction in average tumor volume. |
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Animal Model: |
Male BALB/c nude (nu/nu) athymic mice (6-7 weeks old) injected with PC-3 cells |
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Dosage: |
5mg/kg |
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Administration: |
Intraperitoneal injection; daily; for 38 days |
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Result: |
Caused a significant reduction in average tumor volume. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )