| 中文名称: | BMS-779788 | ||||
|---|---|---|---|---|---|
| 英文名称: | BMS-779788 | ||||
| 别名: | LXR BMS788; XL-652; 2-(2-(2-(2-chlorophenyl)propan-2-yl)-1-(3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-4-yl)propan-2-ol | ||||
| CAS No: | 918348-67-1 | 分子式: | C28H29ClN2O3S | 分子量: | 509.06 |
| CAS No: | 918348-67-1 | ||||
| 分子式: | C28H29ClN2O3S | ||||
| 分子量: | 509.06 | ||||
一种LXR的部分激动剂，对LXRα和LXRβ的IC50值分别为68和14μM。
BMS-779788 is potent partial LXR agonist with LXRβ selectivity, which has an improved therapeutic window in the cynomolgus monkey compared with a full pan agonist. BMS-779788 induced LXR target genes in blood in vivo with an EC50 = 610 nM, a value similar to its in vitro blood gene induction potency. BMS-779788 was 29- and 12-fold less potent than the full agonist T0901317 in elevating plasma triglyceride and LDL cholesterol, respectively, with similar results for plasma cholesteryl ester transfer protein and apolipoprotein B.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
