中文名称: 倍他司汀
英文名称: Betahistine
CAS No: 5638-76-6
分子式: C8H12N2
分子量: 136.2
EINEC: 227-086-4
B10220 倍他司汀 97% (psaitong)
沸点:
113-114°C/30 mmHg (lit.)
密度:
0.984 g/mL at 25 °C (lit.)
包装规格:
1g 5g 25g in glass bottle
产品描述:

基本信息

产品编号:

B10220

产品名称:

Betahistine

CAS:

5638-76-6

 

储存条件

粉末

室温

四年

分子式:

C8H12N2

溶于液体

-80℃

6个月

分子量:

136.20

-20℃

1个月

化学名: 

N-methyl-2-(pyridin-2-yl)ethan-1-amine

Solubility (25°C):

 

体外:

 

DMSO

 

Ethanol

 

Water

 

体内(现配现用):

 

1mg/ml表示微溶或不溶。

普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。

 

制备储备液

 

浓度

 

溶液体积

质量

 

1mg

 

5mg

 

10mg

1mM

7.3427mL

36.7134mL

73.4268mL

5mM

1.4685mL

7.3427mL

14.6854mL

10mM

0.7343mL

3.6713mL

7.3427mL

 

生物活性

产品描述

一种组胺类似物和H1受体激动剂,作为血管扩张剂。

靶点

H1 Receptor

H3 receptor

 

体外研究

Betahistine (0-10μM) inhibits [125I]iodoproxyfan binding to membranes of CHO (rH3(445)R) and CHO (hH3(445)R) cells with IC50 values of 1.9μM and 3.3μM,respectively.Lead to Ki values of 1.4μM and 2.5μM,respectively.Betahistine (0-10μM) has a regulating function on cAMP formation in CHO (rH3(445)R),CHO (rH3(413)R),and CHO (hH3(445)R) cells.At low concentrations,betahistine behaves an apparent inverse agonist, and progressively enhances cAMP formation with EC50 values of 0.1nM,0.05nM and 0.3nM,respectively.In contrast,at concentrations higher than 10nM,betahistine inhibits cAMP formation with an EC50 value of 0.1μM in CHO (rH3(445)R) and full agonist activity.

体内研究

Betahistine (intraperitoneal or oral administration;0.1-30mg/kg;single dose) with acute administration has increased telemethylhistamine (t-MeHA) levels with an ED50 of 0.4mg/kg,indicating the inverse agonism.Besides,after acute oral administration,it increases t-MeHA levels with an ED50 of 2mg/kg in male Swissmice.Betahistine (oral adminstration;1 and 5mg/kg;daily for 3 weeks) attenuates the severity of arthritis and reduces the levels of pro-inflammatory cytokines in the paw tissues of CIA mice.

Animal Model:

Collagen-induced arthritis (CIA) DBA/1 male mouse model

Dosage:

1mg/kg;5mg/kg

Administration:

Oral adminstration;day 21 to day 42 after a 21-day CIA induction

Result:

Ameliorated mouse CIA by decreasing joint destruction.

保存条件:
室温
UN码:
HazardClass:
危害声明:
安全说明:
搜索质检报告(COA)
参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • =
    *
    *
    *选择对应的单位 *空出希望得到的变量,填写另外两个变量

用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )

  • * = *

连续稀释计算器方程

  • 连续稀释

  • 初始浓度:
  • 稀释倍数:
  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):