中文名称: | AG 1295 | ||||
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英文名称: | AG 1295 | ||||
别名: | 酪氨酸磷酸化抑制剂AG1295 6,7-Dimethyl-2-phenylquinoxaline | ||||
CAS No: | 71897-07-9 | 分子式: | C16H14N2 | 分子量: | 234.3 |
CAS No: | 71897-07-9 | ||||
分子式: | C16H14N2 | ||||
分子量: | 234.3 |
基本信息
产品编号:A12626 |
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产品名称:AG 1295 |
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CAS: |
71897-07-9 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
六个月 |
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分子量 |
234.30 |
-20℃ |
一个月 |
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化学名: |
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Solubility (25°C) |
体外 |
DMSO |
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Ethanol |
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Water |
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体内(现配现用) |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
4.2680mL |
21.3402mL |
42.6803mL |
5mM |
0.8536mL |
4.2680mL |
8.5361mL |
10mM |
0.4268mL |
2.1340mL |
4.2680mL |
生物活性
产品描述 |
一种选择性血小板衍生生长因子受体 (PDGFR) 酪氨酸激酶抑制剂。AG1295 能抑制 PDGFR 的自磷酸化,对 EGF 受体的自磷酸化无效。 |
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靶点/IC50 |
PDGFR |
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体外研究 |
AG 1295 inhibits PDGFR autophosphorylation with IC50s of 0.3-0.5μM and 0.5-1μM for membrane autophosphorylation assays and Swiss 3T cells,respectively.AG1295(10μM,100μM)significantly inhibits rabbit conjunctival fibroblast cell growth stimulated by PDGF-AA or PDGF-BB in vitro. Cell Viability Assay |
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Cell Line: |
Rabbit conjunctival fibroblasts cells |
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Concentration: |
1μM, 10μM, 100μM |
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Incubation Time: |
3 days |
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Result: |
Inhibited rabbit conjunctival fibroblast cell growth stimulated by PDGF-AA or PDGF-BB. |
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体内研究 |
AG-1295 reduces neointimal formation in aortic allograft vasculopathy by inhibition of PDGFR-beta-triggered tyrosine phosphorylation.AG1295 (12mg/kg; i.p.; daily; for 14 or 21 days) significantly reduces interstitial fibrosis as verified by a smaller Sirius-Red stained area and also by a reduced number of macrophages, and by the ED-A+ fibronectin deposition and the number of cells positive for alpha-smooth muscle actin. |
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Animal Model: |
Sprague-Dawley rats (240-270g) |
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Dosage: |
12mg/kg |
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Administration: |
Intraperitoneal injection; daily; for 14 or 21 days. |
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Result: |
Attenuated interstitial fibrosis in rat kidney after unilateral obstruction. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )