中文名称: | AZD1080 | ||||
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英文名称: | AZD1080 | ||||
别名: | AZD1080 (Z)-3-(5-(orpholinoethyl)pyridin-2(1H)-ylidene)-2-oxoindoline-5-carbonitrile | ||||
CAS No: | 612487-72-6 | 分子式: | C19H18N4O2 | 分子量: | 334.38 |
CAS No: | 612487-72-6 | ||||
分子式: | C19H18N4O2 | ||||
分子量: | 334.38 |
一种有效的选择性GS3抑制剂。
AZD-1080 is a potent and selective GS3 inhibitor that deonstrates peripheral target engageent in Phase 1 clinical studies. AZD1080 inhibits tau phosphorylation in cells expressing huan tau and in intact rat brain. Interestingly, subchronic but not acute adinistration with AZD1080 reverses -801-induced deficits, easured by long-ter potentiation in hippocapal slices and in a cognitive test in ice, suggesting that reversal of synaptic plasticity deficits in dysfunctional systes requires longer ter odifications of proteins downstrea of GS3β signaling.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )