阿尼芬净 - CAS:166663-25-8 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	阿尼芬净
英文名称:	Anidulafungin
CAS No:	166663-25-8	分子式:	C₅₈H₇₃N₇O₁₇	分子量:	1140.24
CAS No:	166663-25-8
分子式:	C₅₈H₇₃N₇O₁₇
分子量:	1140.24

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A10116 阿尼芬净 ≥98%(HPLC) (psaitong)

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包装规格：

5mg 25mg 100mg in glass bottle

溶解性：

溶于DMSO(2mg/mL)。

产品描述：

基本信息

产品编号：A10116
产品名称：Anidulafungin
CAS:	166663-25-8	储存条件	粉末	-20℃（避光）	四年

分子式：	C58H73N7O17		溶于液体	-80℃（避光）	两年
分子量	1140.24			-20℃（避光）	一个月
化学名：	N-[(3S,6S,9S,11R,15S,18S,20R,21R,24S,25S,26S)-6-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,21,25-tetrahydroxy-3,15-bis[(1R)-1-hydroxyethyl]-26-methyl-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-
Solubility (25°C)	体外	DMSO	100mg/mL warmed with 50ºC water bath (87.7mM)
		Ethanol	8mg/mL warmed with 50ºC water bath (7.01mM)
		Water	Insoluble
	体内	现配现用
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	0.8770mL	4.3850mL	8.7701mL
5mM	0.1754mL	0.8770mL	1.7540mL
10mM	0.0877mL	0.4385mL	0.8770mL
50mM	0.0175mL	0.0877mL	0.1754mL

生物活性

产品描述

一种半合成的棘球蛋白，用作抗真菌药物。

靶点/IC₅₀

glucan synthase

体外研究

Anidulafungin (LY-303366) has MICs of ≤0.32μg/mL for all Candida albicans (n=99), Candida glabrata (n=18), and Candida tropicalis (n=10) isolates tested. Anidulafungin is also active against Aspergillus species (minimum effective concentration at which 90% of the isolates are inhibited, 0.02μg/mL) (n=20), is less active against Candida parapsilosis (MIC at which 90% of the isolates are inhibited [MIC90], 5.12μg/mL) (n=10), and is inactive against C. neoformans (MIC90 >10.24μg/mL) (n=15) and B. dermatitidis (MIC90, 16μg/mL) (n=29).The MICs of Fluconazole for three strains of C. tropicalis, seven strains of C. glabrata, and two strains of Candida krusei are ≥16μg/mL. The MICs of Anidulafungin for 11 of these 12 strains range from 0.08 to 0.32mg/mL. The twelfth strain is a C. krusei strain (Fluconazole MIC, 32μg/mL) for which the Anidulafungin MIC is 1.28mg/mL. The MIC at which 90% of the isolates are inhibited(MIC90) for these 12 strains is 0.32μg/mL. The Anidulafungin MIC90 for the remaining 18 C. glabrata isolates and C. tropicalis isolates for which the Fluconazole MICs are ≥ 8μg/mL is also 0.32mg/mL. Anidulafungin appeares equally active against Candida species for which the fluconazole MICs are ≥16 mg/mL and against those for which the fluconazole MICs are ≥ 8μg/mL. Anidulafungin has significantly less activity against C. neoformans and B. dermatitidis than against C. albicans, C. glabrata, and C. tropicalis. Ketoconazole and amphotericin B are the most active antifungal agents tested for both C. neoformans and B. dermatitidis. Anidulafungin demonstrated potent in vitro activity against Aspergillus species with a MEC90 of 0.02μg/mL. MICs of Anidulafungin for the control strain yeast isolates are 0.02μg/mL for C. albicans ATCC 90028, 0.16mg/mL for C. glabrata ATCC 90030, and >10.24μg/mL for C. neoformans ATCC 90112. Strains selected with CD101 that have a 2-fold or greater CD101 MIC increase also have at least a 2-fold MIC increase for Anidulafungin (ANF) and/or Caspofungin (CSF).

推荐实验方法(仅供参考)

细胞实验:

Cell Assay

Stocks of CD101 (formerly SP 3025, biafungin, AF-025) are prepared fresh in 100% DMSO prior to use. The comparator antifungals Anidulafungin (ANF), Caspofungin (CSF), and Amphotericin B (AMB) are also prepared in 100% DMSO. MIC assays are performed via broth microdilution in accordance with CLSI guidelines, with the exception that test compounds are made up at a 50× final assay concentration and 100μL assay mixture volumes are used (2μL added to 98μL of broth containing cells at 0.5×103 to 2.5×103 CFU/mL). All MIC assays are run at least three times, and a representative data set is shown. Quality control (QC) is assessed throughout the study via comparison of MIC values derived for WT C. krusei strain ATCC 6258 for AMB, CSF, and ANF with previously reported CLSI 24-h broth microdilution QC ranges.

保存条件：

-20℃

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HazardClass：

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